[2], InChI=1S/C22H42N4O8S2/c1-21(2,13-27)17(31)19(33)25-7-5-15(29)23-9-11-35-36-12-10-24-16(30)6-8-26-20(34)18(32)22(3,4)14-28/h17-18,27-28,31-32H,5-14H2,1-4H3,(H,23,29)(H,24,30)(H,25,33)(H,26,34), InChI=1/C22H42N4O8S2/c1-21(2,13-27)17(31)19(33)25-7-5-15(29)23-9-11-35-36-12-10-24-16(30)6-8-26-20(34)18(32)22(3,4)14-28/h17-18,27-28,31-32H,5-14H2,1-4H3,(H,23,29)(H,24,30)(H,25,33)(H,26,34), O=C(NCCSSCCNC(=O)CCNC(=O)C(O)C(C)(C)CO)CCNC(=O)C(O)C(C)(C)CO, Except where otherwise noted, data are given for materials in their, "Pantethine, a derivative of vitamin B5, favorably alters total, LDL and non-HDL cholesterol in low to moderate cardiovascular risk subjects eligible for statin therapy: a triple-blinded placebo and diet-controlled investigation", Calcitriol (1,25-dihydroxycholecalciferol), https://en.wikipedia.org/w/index.php?title=Pantethine&oldid=992895870, Pages using collapsible list with both background and text-align in titlestyle, Articles containing unverified chemical infoboxes, Creative Commons Attribution-ShareAlike License, This page was last edited on 7 December 2020, at 17:58. 10 (right). 33.27. A pantothenic acid hydrolase (pantothenase) activity has been isolated from Pseudomonas fluorescens and other Pseudomonas strains.226 This enzyme hydrolyzes the amide bond of pantothenic acid 2 to form pantoic acid 5 (or pantoyl lactone) and β-alanine 7 (EC 3.5.1.22) (Equation (10)).227 A detailed kinetic study of the reaction mechanism has shown that the reaction is partially reversible because of the formation of an acyl–enzyme (pantoyl–enzyme) intermediate during the course of catalysis, which may react with either water or β-alanine to form pantoic acid (the product hydrolysis) or pantothenic acid (the original substrate)228 Such a mechanism suggests that this enzyme could act as a pantothenate synthase, as reaction of the active site serine with pantoyl lactone would result in the formation of the pantoyl–enzyme intermediate. In multiple clinical trials of patients with elevated cholesterol and triglycerides, total and LDL cholesterol were decreased by an average of 12%, triglycerides decreased by 19%, and HDL cholesterol was increased by 9% in clinical trials with daily intakes ranging from 600 to 1200 mg/day. Vitamin synthesis is reduced with diets high in cellulose but increases with higher quantities of soluble carbohydrates (Virtanen, 1966). 5 mg/day. Panthenol is broadly used in cosmetic products and has become an essential ingredient in skin- and hair-care products. Camille G. Wermuth, in The Practice of Medicinal Chemistry (Second Edition), 2003. About 7–10 mg day−1 (measured as pantothenic acid). Postaire has applied the over-pressure derivatization technique following separation of calcium pantothenate from other hydrophilic vitamins on silica gel HPTLC layers developed in butan-1-ol–pyridine–water (50:35:15). The product of this proton removal is a reactive anion which is able to undergo formation or cleavage of carboncarbon bonds or dehydrogenation by the riboflavin-containing FAD, as shown in Fig. Standard methods for thiamine determination using fluorimetric detection are also detailed in the AOAC methods; in addition, LC techniques are now being used routinely for thiamine and other B vitamins, e.g., riboflavin. For growth and reproduction, the majority of animal species have a dietary requirement between 5 and 15 mg per kg (2.3 to 6.8 mg per lb) of diet. Only the natural dextrorotatory form is active. This can be essentially ascribed to a low water solubility due to strong interaction forces in the crystal lattice. Pantothenic Acid (Vitamin B 5) Pantothenic acid is required in the formation of acetyl coenzyme A which holds a key position in many metabolic pathways. What is known is that high doses of the related vitamin - pantothenic acid - has no effect on lipids. Fig. Liver Milk Egg Whole grain bread Peas Tomato Biological functions of the vitamin In the organism, pantothenic acid NAD and NADP. Most vitamin B5 supplements are in the form of calcium pantothenate, a salt of pantothenic acid, with doses in the range of 5 to 10 mg/day. In contrast, pantethine is sold as a dietary supplement for lowering blood cholesterol and triglycerides at doses of 500 to 1200 mg/day. In Neidhardt FC, Curtiss R, Gross CA, Ingraham JL, Lin ECC, Low KB, Magasanik B, Reznikoff W, Riley M, Schaechter M, and Umbarger HE (ed), Escherichia coli and Salmonella typhimurium: Cellular and Molecular Biology. Since it consists of pantoic acid linked through an amide linkage to β-alanine, chemical hydrolysis cannot be used. V. Spitzer, U. Höller, in Encyclopedia of Analytical Science (Second Edition), 2005. Since it consists of pantoic acid linked through an amide linkage to β-alanine, chemical hydrolysis cannot be used. 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